A Comparison between Water and Ethanol Extracts of Rumex acetosa for Protective Effects on Gastric Ulcers in Mice
The purpose of this study was to evaluate the anti-ulcer activity of Rumex Acetosa (sorrel plant) using a HCI/ethanol-induced gastric ulcer model in mice. The study compared a water extract with an ethanol extract of the plant and examined the free radical-scavenging of the two, along with the protective effects when used as a pre-treatment/preventative measure. The study demonstrated that the ethanol extract had a higher protective effect than the water extract and could in fact reverse changes in inflammation, edema and hemorrhaging. The researchers concluded that ethanol is recommended as an effective solvent for R. acetosa to treat gastritis or gastric ulcers.
Published:
Biomolecules & Therapeutics: Biomol Ther 20(4), 425-430 (2012)©2012 the Korean Society of Applied Pharmacology
Attribution:
Ji-Yeong Bae¹, Yun-Seok Rhee¹, Sun Young Han¹, Eun Ju Jeong², Mi Kyeong Leeᶟ, Jae Yang Kong¹, Dong Hoon Lee⁴, Kyeong Jae Cho⁴, Haeng-Soon Lee⁵, and Mi-Jeong Ahn¹; ¹College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, ²Department of Agronomy and Medicinal Plant Resources, Gyeongnam Nathional University of Science and Technology, ᶟCollege of Pharmacy, Chungbuk National University, ⁴Department of anatomy, School of Medicine and Institute of Health Sciences, Gyeongsang National University, ⁵Environment Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology