Arctigenin inhibits prostate tumor cell growth in vitro and in vivo

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Phytochemicals found in fruits and vegetables are extremely beneficial and are recommended as cancer fighting agents. However the rate and amount that can be absorbed can limit their effect. The purpose of this study was to examine the potency of Arctigenin, a highly studied phytochemical found in Arctium lappa (burdock) known to have anti-carcinogenic properties. In addition to in vitro experiments the researchers conducted in vivo experiments using mice infected with human prostrate cancer. Their results showed that anti-tumor potency of Arctigenin was 10 to 20 times stronger than other popular phytochemicals such as green tea polyphenals and curcumin. Arctigenin was absorbed easily in the mice tissue and showed no toxicity. They concluded that Arctigenin is a promising chemoprevention for prostrate cancer and could be used as a treatment. They recommend human clinical trials.

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Published:

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Clinical Nutrition Experimental Volume 13, June 2017, Pages 1-11 doi:10.1016/j.yclnex.2017.04.001

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Attribution:

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Piwen Wang¹ ² ᶟ, Walter Solorzano¹, Tanya Diaz¹, Clara E. Magyar², Susanne M. Henningᶟ, JayduttV. Vadgama¹ ⁴ ; ¹Division of Cancer Research and Training, charles R. Drew University of Medicine and Science, Los Angeles, CA, USA, ²Department of Pathology, School of Medicine, University of California, Los Angeles, CA, USA, ᶟCenter for Human Nutrition, School of Medicine, University of California, Los Angeles, CA, USA, ⁴David Geffen, School of Medicine, University of California, Los Angeles, CA, USA

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Link:

https://www.sciencedirect.com/science/article/pii/S235293931730009X