Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor
Numerous studies show that obesity increases the risk of prostrate cancer and can also complicate treatment, therefore it is important to find therapies that will treat both obesity and cancer simultaneously. This study tested the effects of arctigenin (a compound found in Arctium lappa/Burdock) both in vitro and in vivo on prostrate cancer in obese conditions. Researchers concluded that arctigenin inhibited the growth of prostrate cancer cells by decreasing the level of pro-inflammatory agents in vitro. In addition, arctigenin was responsible for decreasing free fatty acids in a high-fat diet given to mice while at the same time improving the activity of a known tumor suppressor. Arctigenin appears to treat obesity while also inhibiting the growth of prostrate cancer.
Published:
Scientific Reports 2020 10:1403, doi 10.1038/s41598-020-58354-3
Attribution:
Qiongyu Hao¹ ⁵, Tanya Diaz¹, Alejandro del Rio Verduzco¹, Clara E. Magyar², Jin Zhong⁶ ⁷, Yahya Elshimali¹, Matthew B. Rettigᶟ, Susanne M. Henning⁴, Jaydutt V. Vadgama¹ ⁵ and Piwen Wang¹ ⁴ ⁵ ; ¹Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA ²Department of Pathology, University of California, Los Angeles, CA, USA ᶟDepartments of Medicine and Urology, University of California, Los Angeles, CA, USA ⁴Center for Human Nutrition, University of California, Los Angeles, CA, USA ⁵David Geffen School of Medicine, University of California, Los Angeles, CA, USA ⁶VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA ⁷University of California, Riverside, CA, USA