Arctium lappa Root Extract Prevents Lead-Induced Liver Injury by Attenuating Oxidative Stress and Inflammation, and Activating Akt/GSK-3β Signaling

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This study examined the protective effect of Arctium lappa root extract (burdock) on lead toxicity in rats. Lead is a serious environmental toxin and prolonged exposure can lead to neurological disorders and numerous cancers. Researchers have identified that lead causes oxidative stress and harmful inflammation. All rats were administered a lead acetate to induce toxicity in the livers. The control group of rats was given a saline solution orally and other test groups were given either with an Arctium lappa extract or a combination of the extract and Vitamin C. This study presents new evidence about the protective effects of Arctium lappa on liver toxicity related to the Akt/glycogen synthase kinase signaling, suggesting this important pathway is moderated by the phytochemicals contained in Arctium lappa.

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Published:

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MDPI: Antioxidants 2019, 8, 582; doi:10.3390/antiox8120582

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Attribution:

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Ahlam Alhusaini¹, Laila Fadda¹, Iman Hasan¹, Hanaa M. Ali² ᶟ, Naglaa F. El Orabi¹ ⁴, Amira M. Badr¹ ⁵, Enas Zakaria⁶, Abeer M. Alenazi¹, and Ayman M. Mahmoud⁷; ¹Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Saudi Arabia, ²Common First Year Deanship, King Saud University, Saudi Arabia, ᶟGenetic and Cytology Department, National Research Centre, Giza, Egypt, ⁴Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt, ⁵Faculty of Pharmacy, Ain Shams University, Cairo, Egypt, ⁶Pharmaceutics Department, College of Pharmacy, King Saud University, Saudi Arabia, ⁷Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

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Link:

https://www.mdpi.com/2076-3921/8/12/582/htm

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